![]() None were adequately described in the medical literature. Colleagues in the field of metabolic diseases said they were probably from gut flora (microorganisms) and were therefore unimportant. Instead, I noticed that several unusual compounds were consistently elevated in urine samples. Since some inborn errors of metabolism are associated with muscle weakness, I was really looking for metabolites characteristic of genetic diseases which were all negative. Later, while working at Children’s Mercy Hospital, the pediatric hospital for the University of Missouri at Kansas City Medical School, I became interested in the role of abnormal urinary metabolites detected by GC/MS while evaluating two brothers who had autism as well as occasional severe muscle weakness. ![]() At CDC, GC/MS was used to identify the species of pure cultures of isolated bacteria. I wondered why you couldn’t directly test human body fluids directly for products of microorganisms. I became interested in using gas chromatography-mass spectrometry (GC/MS) to detect abnormal microbial metabolites when I worked at the Center for Disease Control (CDC). DETECTING GI MICROBIAL OVERGROWTH (DYSBIOSIS) ![]() Furthermore, recent research indicates that the growth of certain Candida types is markedly stimulated by antibiotic addition to the culture media.īooks like The Yeast Connection and Yeast Syndrome have spread the knowledge about the health effects of Candida to the general public, but are widely ignored by a large segment of the medical community. The greatest number of species are anaerobic or facultative anaerobes. Yeast/fungi and Clostridia species are widely known to accompany the use of broad spectrum antibiotics. Approximately 500 species of bacteria are present, of which 30-40 species of bacteria predominate, including several species of yeast and fungi. The number of microorganisms in the GI tract approaches the total number of cells in the body. There is a long list of diseases in which a substantial number of patients excrete elevated microbial metabolites in the urine which have been detected by urine organic acid testing: However, thirty years later, very little progress had been made in solving the mystery of a number of diseases like autism, fibromyalgia, schizophrenia, and Alzheimer’s disease. It seemed possible that this new testing called organic acid testing or metabolic profiling might be applied to any disease. These diseases included phenylketonuria (PKU), tyrosinemia, maple syrup urine disease and many others. In the 1960’s, a great deal of progress had been made in discovering the biochemical abnormalities that caused a number of diseases called "inborn errors of metabolism" using a technology called gas chromatography-mass spectrometry. My discovery about the role of abnormal organic acids from gastrointestinal microorganisms in human disease began as many discoveries do, as an accident. Candida and yeast overgrowth THE YEAST PROBLEM & BACTERIA BYPRODUCTS
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